Job Title: Senior/Principal Scientist Line Manager: Head of Early Validation Team: Cell & Tissue Biology Location: Taipei City, Taiwan Contract: Permanent Summary We are looking for a talented and highly motivated senior/principal scientist to join the Ochre Bio Team in TPE on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. Ochre’s Taipei site is a highly unique precision-slice liver culture lab that deep phenotypes human liver biopsies from diseased donor patients and studies their responses to advanced RNA therapies. Deep phenotyping of liver tissue slices includes: tissue imaging, functional assays, bulk/single-cell sequencing, to model disease and therapeutic dynamics over extended culture time. The team also uses functional genomics, perturbation assays and large scale primary human cell culture/co-culture models to increase scale and throughput of generating discovery datasets and drug candidate screening. This role will be responsible for driving innovation using the ex-vivo human precision slice culture and human primary cell culture to better study liver fibrosis and regeneration and for early validation of Ochre’s drug discovery candidates. We are looking for well-rounded scientists who can keep to deadlines in a fast-paced environment and be part of a collaborative team. You will be expected to work alongside junior scientists to rapidly optimise culture conditions and assays to drive innovation in precision slice culture systems. Experimental experience in liver and metabolic disorders, ex vivo tissue perfusion systems, organ-on-chip, 3D organoid cultures, high-content imaging, RNAi screens will be highly advantageous. We welcome Ph.Ds and Post Docs who would like to make the switch to an industrial research environment. You will report to the Head of Early Validation (site head), working closely with the rest of cell and tissue team to generate robust data. This role will be based at National Biotechnology Research Park at Nangang, Taipei. Key Responsibility ● Drive innovation by developing and executing state of the art primary cell and tissue culture conditions to study liver fibrosis and regeneration ● Lead the design and execution of large scale RNAi screen in liver cells and tissue to identify new targets in liver fibrosis and regeneration ● Actively collaborate and communicate with other members of Ochre Bio across all three sites (US, UK & Taiwan) and attend meetings ● Support junior scientists in the lab ● Compile data decks on experiments, present data and conclusions to wider teams ● Participate in projects spanning all three sites (US, UK & Taiwan) and external partners Qualification and Skills Required ● PhD degree in a biological science or MSc with equivalent industry experience ● Track record of scientific contributions including peer-reviewed first-author publications, patent applications ● Strong command of biology, cellular models and model development ● Comfortable with large scale screens and high-throughput workflows ● Ability to adapt to changing demands whilst working within a team to tight deadlines ● Strong organisational skills, with the ability to coordinate multiple projects and prioritise tasks effectively ● Good team player ● Excellent command of English ● Embracing change - this is a fast-growing company and change is inevitable! Desirable ● Startup biotech or industry experience ● Experience with 3D tissue and organoid culture, organ-on-chip, perfusion system, high-content imaging, large scale RNAi screens ● Ability to analyse and present data using R is highly desirable, and will be required on the job. We'd love to hear from you: Please apply with your CV and a cover letter clearly stating: Your earliest start date.1-2 examples of work (or publications) you feel best highlight your scientific strengths and ability to meet demanding deadlines.

Job Title: Research Assistant I/II Line Manager: Head of Early Validation Team: Cell & Tissue Biology Location: Taipei City, Taiwan Contract: Permanent Summary We are looking for a talented and highly motivated senior/principal scientist to join the Ochre Bio Team in TPE on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. Ochre’s Taipei site is a highly unique precision-slice liver culture lab that deep phenotypes human liver biopsies from diseased donor patients and studies their responses to advanced RNA therapies. Deep phenotyping of liver tissue slices includes: tissue imaging, functional assays, bulk/single-cell sequencing, to model disease and therapeutic dynamics over extended culture time. The team also uses functional genomics, perturbation assays and large scale primary human cell culture/co-culture models to increase scale and throughput of generating discovery datasets and drug candidate screening. This role will be responsible for generating experimental data from Taipei lab, to support cell and tissue assays for early validation of Ochre’s drug discovery candidates. We are looking for well-rounded scientists who can keep to deadlines in a fast-paced environment and be part of a collaborative team. You will be expected to work alongside senior scientists to rapidly optimise challenging assays, imaging, and omic outputs. Experimental experience in liver and metabolic disorders, 2D/3D precision cut tissue and cell cultures, high-content imaging, single cell/spatial transcriptomics, CRISPR-Cas9, RNAi screens and excellent proficiency in molecular biology and biochemistry will be highly advantageous. We welcome fresh Ph.Ds and Post Docs who would like to make the switch to industrial research environment. You will report to the Head of Early Validation (site head), working closely with the rest of cell and tissue team to generate robust data, Key responsibilities - Prepare ex vivo tissue samples and for early validation studies - Assist in transportation of clinical samples from hospital to the lab - Assist in expanding and maintaining of human primary cellline culture - Generating data reliably using molecular biology methods such as qPCR, immunoassays (ELISA, AlphaLISA), DNA, RNA and protein isolation - Assist in genomic workflows such as nuclei isolation, single-cell RNA-sequencing and histology workflows such as sectioning of tissue block, immunohistochemistry and microscopy. Experience and independence in working on genomic or histology workflow is a plus. - Keeping site inventory and ensuring a safe and clean work environment - Supports development and management of research protocols and documentation of data - Actively collaborate and communicate with other members of Ochre Bio across all three sites (US, UK & Taiwan) and attend meetings Essential Requirements -M.Sc. in a relevant field or equivalent experience - Experience with cellular models using sterile technique - Highly organised and methodical approach to work and record keeping - Self-motivated, technically competent and capable of working independently within the laboratory - Ability to adapt to changing demands whilst working within a team to tight deadlines - Basic data analysis, formatting and presentation skills - Computing skills in packages such as Word, Excel, Powerpoint and/or GSuite - Ability to learn quickly and work in a fast-paced environment - High-level of attention to detail - Excellent interpersonal skills and good team player - Embracing change - this is a fast-growing company and change is inevitable! We'd love to hear from you: Please apply with your CV and a cover letter clearly stating: Your earliest start date.1-2 examples of work (or publications) you feel best highlight your scientific strengths and ability to meet demanding deadlines.

We're looking for talented Research Associates to join our young company! This is an unique opportunity to join an multi-national (Oxford/Taipei/NewYork) biotech in the field of RNA drug discovery and liver diseases. Position: Part-Time Weekend Laboratory Assistant Location: Ochre-Bio, Taipei Job Type: Part-Time (Weekends) Responsibilities: • Assist with laboratory experiments and procedures during the weekend. • Perform tasks such as changing culture media, harvesting experiment samples, and preparing reagents. • Follow standard operating procedures (SOPs) and protocols under the supervision of senior laboratory staff. • Document experimental procedures, observations, and results accurately. • Adhere to safety regulations and protocols at all times. • Communicate effectively with laboratory team members regarding experiment progress Requirements: • Previous laboratory experience or coursework in biology, chemistry, or a related field preferred. Students are welcome to apply. • Strong attention to detail and ability to perform tasks accurately and precisely • Self-motivated, technically competent and capable of working independently within the laboratory • Good communication skills and willingness to learn and follow instructions. • Flexibility to adapt to changing priorities and experiment schedules. • We prefer candidates who reside in or in the vicinity of Nangang area. Working Hours: Part-time position, working weekends (Saturday and/or Sunday). Flexible scheduling based on laboratory experiment needs and availability. Benefits: Competitive hourly wage.